Evaluation of toxicity of gadolinium based contrast agents on skin fibroblasts
نویسندگان
چکیده
Introduction: Gadolinium based contrast agents have been reported to induce nephrogenic systemic fibrosis (NSF) in patients with impaired renal function. Skin fibrosis is a characteristic symptom while the mechanism of causing NSF is unclear. In this study, we investigated the cytotoxicty Gd(III)-based contrast agents, including Omniscan®, Mutihance® and ProHance®, to normal rat skin fibroblasts and effect of gadolinium(III) deposition and transmetallation on their cytotoxicity.
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